Many Graduates from the School of Library and Information Science or the Department of Library and Information Science are in leadership positions. Among them:
- Alcione Amos – Museum Curator, Smithsonian Anacostia Community Museum
- Ruben Aragón – Director, New Mexico Highlands University Donnelly Library and Chairman of the Board, Amigos Library Services
- Betsy Fowler – Director, Williamsburg Regional Library
- Anna K. Gold – University Librarian, Worcester Polytechnic Institute
- Laurie Beyer Hall – Superintendent of Documents, Government Publishing Office
- Marin Kalfatovic – Associate Director, Smithsonian Libraries and Program Director, The Biodiversity Heritage Library
- Angela Kinney, Chief, African, Latin American and Western European Division, Library of Congress
- Cait Kokolus, Vice-President for Information Services and Assessment & Director of the Philadelphia Archdiocesan Historical Records Center
- Diane Kresh – Director, Department of Libraries, Arlington, VA
- Derryn Moten – Acting Chair, Department of History and Political Science, Alabama State University
- Jerome Offord, Associate University Librarian for Antiracism, Harvard University
- Andrew Kingsley Pace – Executive Director, Worldshare Community Development, OCLC, Dublin, OH
- Ned Quist – Associate University Librarian for Research and Outreach Services, Brown University
- Judith C. Russell – Dean of University Libraries, University of Florida, and former Superintendent of Documents, Government Printing Office (1st woman to hold position)
- Brent Short – Director of Library Services, Saint Leo University, Florida
- Dick Spottswood – Musicologist and radio show host
- Mark Sweeney – Principal Deputy Librarian of Congress
- Mary Augusta Thomas – Deputy Director, the Smithsonian Libraries
- Maggie Warnken – President, Health Data Solutions, Portland, OR
- Sohair Wastawy – Executive Director, Qatar National Library
